Repeatability of Cerebral Perfusion Using Dynamic Susceptibility Contrast MRI in Glioblastoma Patients

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Repeatability of Cerebral Perfusion Using Dynamic Susceptibility Contrast MRI in Glioblastoma Patients.

OBJECTIVES This study evaluates the repeatability of brain perfusion using dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) with a variety of post-processing methods. METHODS Thirty-two patients with newly diagnosed glioblastoma were recruited. On a 3-T MRI using a dual-echo, gradient-echo spin-echo DSC-MRI protocol, the patients were scanned twice 1 to 5 days apart. Perfu...

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Repeatability of Cerebral Perfusion Using Dynamic Susceptibility Contrast MRI in Glioblastoma Patients12

correspondence to: Kourosh Jafari-Khouzani, PhD, Athinoula A. Martinos Biomedical Imaging, Department of Radiology, Massachusetts General 49 Thirteenth Street, Suite 2301, Charlestown, MA 02129, USA. [email protected] rk was supported by NCI/NIH R21CA117079, R01CA129371, and 440 (T.B.); NIH S10RR023401, 5R01NS069696, and 5R01NS060918 aic-Frederick Inc. grant 26XS263 (T.B.); Norwegian Res...

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Dynamic susceptibility contrast perfusion MRI (with pitfalls)

Since the first studies in the late 1980s and early 1990s, dynamic susceptibility contrast MRI (DSC-MRI, also known as ‘bolus tracking’) has become a very powerful technique for the assessment of perfusion, and perfusion-related parameters (see (1,2) for recent reviews). Despite the need of an exogenous MR agent (cf. arterial spin labeling techniques), DSC-MRI is currently the most common MR pe...

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BACKGROUND AND PURPOSE DSC perfusion has been increasingly used in conjunction with other contrast-enhanced MR applications and therefore there is need for contrast-dose reduction when feasible. The purpose of this study was to establish the feasibility of reduced-contrast-dose brain DSC perfusion by using a probabilistic Bayesian method and to compare the results with the commonly used singula...

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ژورنال

عنوان ژورنال: Translational Oncology

سال: 2015

ISSN: 1936-5233

DOI: 10.1016/j.tranon.2015.03.002